冯陈国

发布者:创新中药1发布时间:2021-04-25浏览次数:581

姓名:冯陈国性别:
职称:研究员学历:博士研究生
专家类别:
职务:
电话:021-51322416传真:
电子邮箱:fengcg(at)shutcm.edu.cn
通讯地址:上海市蔡伦路1200号 上海中医药大学 邮编:201203
个人主页:

招生专业:

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
创新中药研究院理学中药学100800/中药学学术型硕士

个人简历:

2017.05-目前
研究员,上海市中医药大学创新中药研究院手性药物研究中心
2014.05-2017.05副研究员,中国科学院上海有机化学研究所
2011.08-2013.08访问学者,美国Scripps研究所,导师:Jin-Quan Yu(余金权)教授
2006.09-2009.06助理研究员,中国科学院上海有机化学研究所
2004.09-2006.09研究实习员,中国科学院上海有机化学研究所
2001.09-2004.09理学硕士,厦门大学化学系有机合成专业,导师:黄培强教授
1997.09-2001.06理学学士,浙江大学化学系,导师:林贤福教授

研究内容:

中药活性成分有机合成和结构改造
方法学导向的天然产物和药物分子合成
药物分子合成工艺优化
过渡金属催化的高效和高选择性反应研究

学术荣誉:

2016年 上海市自然科学一等奖(第四完成人)
2016年 国家自然科学二等奖(第四完成人)
2020年 上海市青年优秀学术带头人
2020年 德国蒂姆杂志社Thieme Chemistry Journals Award

主持科研项目:

课题名称项目名称起止时间金额
中药创新中的分子后修饰标记研究上海市科委青年优秀学术带头人计划 2020.10-2023.0940万
基于烯丙基钯β-烯基氢消除的手性联烯合成研究 (91956113)国家自然科学基金重大研究计划培育项目2020.01-2022.1275万
导向合成方法学的可控过渡金属迁移反应研究 (21772216)国家自然科学基金面上项目2018.01-2021.1264万

发表文章:

2021(7):
1. Zhang, Ge; Song, Yi-Kang; Zhang, Fang; Xue, Ze-Jian; Li, Meng-Yao; Zhang, Gui-Shan; Zhu, Bin-Bin; Wei, Jing; Li, Chunsen; Feng, Chen-Guo; Lin, Guo-Qiang Palladium-Catalyzed Allene Synthesis Enabled by Beta-Hydrogen Elimination from Sp2-Carbon. Nature communications 2021, 12, 728-728.
2. Zhang, Ge; Li, Meng-Yao; Ye, Wen-Bo; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang Borylation of Unactivated C(Sp(3))-H Bonds with Bromide as a Traceless Directing Group. Org. Lett. 2021, 23, 2948-2953.
3. Xue, Ze-Jian; Li, Meng-Yao; Zhu, Bin-Bin; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang A 1,4-Palladium Migration/Heck Sequence with Unactivated Alkenes: Stereoselective Synthesis of Trisubstituted 1,3-Dienes. Adv. Synth. Catal. 2021, 363, 2089-2092.
4. Xu, Si-Yu; Zhang, Rui; Zhang, Shu-Sheng; Feng, Chen-Guo Enantioselective Synthesis of 3-Aryl-Phthalides through a Nickel-Catalyzed Stereoconvergent Cross-Coupling Reaction. Organic & Biomolecular Chemistry 2021, 19, 4492-4496.
5. Tian, Tian; Zhou, Bo-wen; Wu, Li-hong; Zhang, Fang; Chou, Gui-xin; Feng, Chen-guo; Lin, Guo-qiang Non-Targeted Screening of Pyranosides in Rhodiola Crenulata Using an All Ion Fragmentation-Exact Neutral Loss Strategy Combined with Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Phytochem. Anal 2021.
6. Song, Yi-Kang; Xu, Si-Yu; Zhang, Shu-Sheng; Fu, Jian-Guo; Lin, Guo-Qiang; Feng, Chen-Guo Palladium-Catalyzed Tandem Gamma-Arylation/Aromatization of Cyclohex-2-En-1-One Derivatives: A Route to 3,4-Dihydroanthracen-1(2h)-Ones. Adv. Synth. Catal. 2021, 363, 3001-3005.
7. Song, Yi-Kang; Liu, Li; Wang, Jun-Jie; Qian, Fei; Yang, Mao-Qi; Zhang, Liu-Qiang; Fu, Jian-Guo; Li, Yi-Ming; Feng, Chen-Guo An Asymmetric Synthesis of (+)-Scrodentoid a from Dehydroabietic Acid. Tetrahedron 2021, 85, 132031.
2020(3):
1. Zhang, Ge; Fu, Jian-Guo; Zhao, Qian; Zhang, Gui-Shan; Li, Meng-Yao; Feng, Chen-Guo; Lin, Guo-Qiang Silver-Promoted Synthesis of Vinyl Sulfones from Vinyl Bromides and Sulfonyl Hydrazides in Water. Chem. Commun. 2020, 56, 4688-4691.
2. Xue, Ze-Jian; Li, Meng-Yao; Zhu, Bin-Bin; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang Stereoselective Synthesis of Conjugated Trienes Via 1,4-Palladium Migration/Heck Sequence. Chem. Commun. 2020, 56, 14420-14422.
3. Li, Meng-Yao; Han, Pengbo; Hu, Tian-Jiao; Wei, Dong; Zhang, Ge; Qin, Anjun; Feng, Chen-Guo; Tang, Ben Zhong; Lin, Guo-Qiang Suzuki-Miyaura Coupling Enabled by Aryl to Vinyl 1,4-Palladium Migration. Iscience 2020, 23, 100966.
2019(5):
1. Zhou, Jing; Zhang, Hong; Chen, Xue-Lian; Qu, Ya-Li; Zhu, Qianqian; Feng, Chen-Guo; Chen, Ya-Jing Regio- and Diastereoselective Access to 4-Imidazolidinones Via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic Imines with Alpha-Halo Hydroxamates. J. Org. Chem. 2019, 84, 9179-9187.
2. Zhang, Shu-Sheng; Hu, Tian-Jiao; Li, Meng-Yao; Song, Yi-Kang; Yang, Xiao-Di; Feng, Chen-Guo; Lin, Guo-Qiang Asymmetric Alkenylation of Enones and Imines Enabled by a Highly Efficient Aryl to Vinyl 1,4-Rhodium Migration. Angew. Chem. Int. Ed. 2019, 58, 3387-3391.
3. Zhang, Ge; Bai, Rui-Xue; Li, Chu-Han; Feng, Chen-Guo; Lin, Guo-Qiang Halogenation of 1,1-Diarylethylenes by N-Halosuccinimides. Tetrahedron 2019, 75, 1658-1662.
4. Wei, Dong; Li, Meng-Yao; Zhu, Bin-Bin; Yang, Xiao-Di; Zhang, Fang; Feng, Chen-Guo; Lin, Guo-Qiang Sequential Cross-Coupling/Annulation of Ortho-Vinyl Bromobenzenes with Aromatic Bromides for the Synthesis of Polycyclic Aromatic Compounds. Angew. Chem. Int. Ed. 2019, 58, 16543-16547.
5. Lv, Shao-Dong; Tian, Tian; Zhang, Liu-Qiang; Xu, Si Yu; Zhao, Dong-Hai; Wang, Jun-Jie; Fu, Jian-Guo; Li, Yi-Ming; Feng, Chen-Guo Total Synthesis of (+/-)-Scrodentoid A. Tetrahedron 2019, 75, 130774-130775.
2018(4):
1. Wei, Dong; Hu, Tian-Jiao; Feng, Chen-Guo; Lin, Guo-Qiang Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes. Chin. J. Chem . 2018, 36, 743-748.
2. Meng, Jiao-Long; Jiao, Tang-Qian; Chen, Ya-Heng; Fu, Rui; Zhang, Shu-Sheng; Zhao, Qian; Feng, Chen-Guo; Lin, Guo-Qiang Synthesis of Chiral Isoindolinones Via Asymmetric Propargylation/Lactamization Cascade. Tetrahedron Lett. 2018, 59, 1564-1567.
3. Hu, Tian-Jiao; Li, Meng-Yao; Zhao, Qian; Feng, Chen-Guo; Lin, Guo-Qiang Highly Stereoselective Synthesis of 1,3-Dienes through an Aryl to Vinyl 1,4-Palladium Migration/Heck Sequence. Angew. Chem. Int. Ed. 2018, 57, 5871-5875.
4. Ge, Yao; Han, Zhaobin; Wang, Zheng; Feng, Chen-Guo; Zhao, Qian; Lin, Guo-Qiang; Ding, Kuiling Ir-Spinphox Catalyzed Enantioselective Hydrogenation of 3-Ylidenephthalides. Angew. Chem. Int. Ed. 2018, 57, 13140-13144.
2017(1):
1. Qian, Xue-Wei; Xue, Ze-Jian; Zhao, Qian; Cui, Zhe; Chen, Ya-Jing; Feng, Chen-Guo; Lin, Guo-Qiang Enantioselective Rhodium-Catalyzed Alkenylation of Aliphatic Lmines. Org. Lett. 2017, 19, 5601-5604.
2016(1):
1. Hu, T. J.; Zhang, G.; Chen, Y. H.; Feng, C. G.; Lin, G. Q. Borylation of Olefin C-H Bond Via Aryl to Vinyl Palladium 1,4-Migration. J. Am. Chem. Soc. 2016, 138, 2897-2900.
2015(3):
1. Dong, Han-Qing; Xu, Ming-Hua; Feng, Chen-Guo; Sun, Xing-Wen; Lin, Guo-Qiang Recent Applications of Chiral N-Tert-Butanesulfinyl Imines, Chiral Diene Ligands and Chiral Sulfur–Olefin Ligands in Asymmetric Synthesis. Org. Chem. Front. 2015, 2, 73-89.
2. Chen, Y. J.; Hu, T. J.; Feng, C. G.; Lin, G. Q. Synthesis of Chiral Cyclobutanes Via Rhodium/Diene-Catalyzed Asymmetric 1,4-Addition: A Dramatic Ligand Effect on the Diastereoselectivity. Chem. Commun. 2015, 51, 8773-8776.
3. Chen, Y. J.; Cui, Z.; Feng, C. G.; Lin, G. Q. Enantioselective Addition of Heteroarylboronates to Arylimines Catalyzed by a Rhodium-Diene Complex. Adv. Synth. Catal. 2015, 357, 2815-2820.
2014(2):
1. Cui, Z.; Chen, Y. J.; Gao, W. Y.; Feng, C. G.; Lin, G. Q. Enantioselective Alkenylation of Aldimines Catalyzed by a Rhodium-Diene Complex. Org. Lett. 2014, 16, 1016-1019.
2. Chen, Y. J.; Chen, Y. H.; Feng, C. G.; Lin, G. Q. Enantioselective Rhodium-Catalyzed Arylation of Cyclic N-Sulfamidate Alkylketimines: A New Access to Chiral Beta-Alkyl-Beta-Aryl Amino Alcohols. Org. Lett. 2014, 16, 3400-3403.
2013(2):
1. Miura, M.; Feng, C. G.; Ma, S.; Yu, J. Q. Pd(Ii)-Catalyzed Ortho-Trifluoromethylation of Benzylamines. Org. Lett. 2013, 15, 5258-5261.
2. Feng, C. G.; Ye, M. C.; Xiao, K. J.; Li, S. H.; Yu, J. Q. Pd(Ii)-Catalyzed Phosphorylation of Aryl C-H Bonds. J. Am. Chem. Soc. 2013, 135, 9322-9325.
2012(3):
1. Yu, Hong-Jie; Shao, Cheng; Cui, Zhe; Feng, Chen-Guo; Lin, Guo-Qiang Highly Enantioselective Alkenylation of Cyclic Alpha,Beta-Unsaturated Carbonyl Compounds as Catalyzed by a Rhodium-Diene Complex: Application to the Synthesis of (S)-Pregabalin and (-)-Alpha-Kainic Acid. Chemistry-a European Journal 2012, 18, 13274-13278.
2. Shao, Cheng; Yu, Hong-Jie; Feng, Chen-Guo; Wang, Rui; Lin, Guo-Qiang Easily Accessible Chiral Dicyclopentadiene Ligands for Rhodium-Catalyzed Enantioselective 1,4-Addition Reactions. Tetrahedron Lett. 2012, 53, 2733-2735.
3. He, Zhi-Tao; Wei, Ya-Bing; Yu, Hong-Jie; Sun, Cai-Yun; Feng, Chen-Guo; Tian, Ping; Lin, Guo-Qiang Rhodium/Diene-Catalyzed Asymmetric Arylation of N-Boc-Protected Alpha,Beta-Unsaturated Delta-Lactam with Arylboronic Acids: Enantioselective Synthesis of 4-Aryl-2-Piperidinones. Tetrahedron 2012, 68, 9186-9191.
2011(3):
1. Shao, Cheng; Yu, Hong-Jie; Wu, Nuo-Yi; Tian, Ping; Wang, Rui; Feng, Chen-Guo; Lin, Guo-Qiang Asymmetric Synthesis of Beta-Substituted Gamma-Lactams Via Rhodium/Diene-Catalyzed 1,4-Additions: Application to the Synthesis of (R)-Baclofen and (R)-Rolipram. Org. Lett. 2011, 13, 788-791.
2. Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang Development of Bicyclo 3.3.0 Octadiene-or Dicyclopentadiene-Based Chiral Diene Ligands for Transition-Metal-Catalyzed Reactions. Synlett 2011, 1345-1356.
3. Cui, Zhe; Yu, Hong-Jie; Yang, Rui-Feng; Gao, Wen-Yun; Feng, Chen-Guo; Lin, Guo-Qiang Highly Enantioselective Arylation of N-Tosylalkylaldimines Catalyzed by Rhodium-Diene Complexes. J. Am. Chem. Soc. 2011, 133, 12394-12397.
2010(2):
1. Wang, Zhi-Qian; Feng, Chen-Guo; Zhang, Shu-Sheng; Xu, Ming-Hua; Lin, Guo-Qiang Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo 3.3.0 Diene Ligands. Angew. Chem. Int. Ed. 2010, 49, 5780-5783.
2. Shao, Cheng; Yu, Hong-Jie; Wu, Nuo-Yi; Feng, Chen-Guo; Lin, Guo-Qiang C-1-Symmetric Dicyclopentadienes as New Chiral Diene Ligands for Asymmetric Rhodium-Catalyzed Arylation of N-Tosylarylimines. Org. Lett. 2010, 12, 3820-3823.
2008(4):
1. Zhou, Jing; Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang; Guo, Yinlong Study on Mass Spectrometric Behavior of Samarium Di-Iodide in Tetrahydrofuran Solution. Int. J. Mass spectrom. 2008, 270, 62-67.
2. Liu, G.; Meng, J.; Feng, C. G.; Huang, P. Q. Asymmetric Syntheses of (-)-Epi-Pseudoconhydrine and (-)-5-Hydroxysedamine Based on a Cis-Diastereoselective 1,4-Asymmetric Induction. Tetrahedron-Asymmetr 2008, 19, 1297-1303.
3. Feng, Chen-Guo; Wang, Zhi-Qian; Tian, Ping; Xu, Ming-Hua; Lin, Guo-Qiang Easily Accessible C2-Symmetric Chiral Bicyclo[3.3.0] Dienes as Ligands for Rhodium-Catalyzed Asymmetric 1,4-Addition. Chemistry-an Asian Journal 2008, 3, 1511-1516.
4. Feng, Chen-Guo; Wang, Zhi-Qian; Shao, Cheng; Xu, Ming-Hua; Lin, Guo-Qiang Highly Practical Catalytic Asymmetric 1,4-Addition of Arylboronic Acids in Water Using New Hydrophilic Chiral Bicyclo[3.3.0] Diene Ligands. Org. Lett. 2008, 10, 4101-4104.
2007(1):
1. Wang, Zhi-Qian; Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang Design of C-2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids. J. Am. Chem. Soc. 2007, 129, 5336-+.
2006(1):
1. Feng, C. G.; Chen, J.; Ye, J. L.; Ruan, Y. P.; Zheng, X.; Huang, P. Q. Syntheses of Enantio-Enriched Chiral Building Blocks from L-Glutamic Acid. Tetrahedron 2006, 62, 7459-7465.
2005(1):
1. Zheng, X.; Feng, C. G.; Ye, J. L.; Huang, P. Q. Samarium Diiodide Promoted Generation and Asymmetric Hydroxyalkylation of N,O-Diprotected (3s)-3-Pyrrolidinol 2-Carbanions. Org. Lett. 2005, 7, 553-556.