| 姓名： | 冯陈国 | 性别： | 男 |
| 职称： | 研究员 | 学历： | 博士研究生 |
| 专家类别： | 职务： | ||
| 电话： | 021-51322416 | 传真： | |
| 电子邮箱： | fengcg(at)shutcm.edu.cn | ||
| 通讯地址： | 上海市蔡伦路1200号 上海中医药大学 邮编：201203 | ||
| 个人主页： | |||
招生专业：
| 院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
| 创新中药研究院 | 理学 | 中药学 | 100800/中药学 | 学术型 | 硕士 |
个人简历：
| 2017.05-目前 | 研究员，上海市中医药大学创新中药研究院手性药物研究中心 |
| 2014.05-2017.05 | 副研究员，中国科学院上海有机化学研究所 |
| 2011.08-2013.08 | 访问学者，美国Scripps研究所，导师：Jin-Quan Yu（余金权）教授 |
| 2006.09-2009.06 | 助理研究员，中国科学院上海有机化学研究所 |
| 2004.09-2006.09 | 研究实习员，中国科学院上海有机化学研究所 |
| 2001.09-2004.09 | 理学硕士，厦门大学化学系有机合成专业，导师：黄培强教授 |
| 1997.09-2001.06 | 理学学士，浙江大学化学系，导师：林贤福教授 |
研究内容：
| 中药活性成分有机合成和结构改造 |
| 方法学导向的天然产物和药物分子合成 |
| 药物分子合成工艺优化 |
| 过渡金属催化的高效和高选择性反应研究 |
学术荣誉：
| 2016年 上海市自然科学一等奖（第四完成人） |
| 2016年 国家自然科学二等奖（第四完成人） |
| 2020年 上海市青年优秀学术带头人 |
| 2020年 德国蒂姆杂志社Thieme Chemistry Journals Award |
主持科研项目：
| 课题名称 | 项目名称 | 起止时间 | 金额 |
| 中药创新中的分子后修饰标记研究 | 上海市科委青年优秀学术带头人计划 | 2020.10-2023.09 | 40万 |
| 基于烯丙基钯β-烯基氢消除的手性联烯合成研究 (91956113) | 国家自然科学基金重大研究计划培育项目 | 2020.01-2022.12 | 75万 |
| 导向合成方法学的可控过渡金属迁移反应研究 (21772216) | 国家自然科学基金面上项目 | 2018.01-2021.12 | 64万 |
发表文章：
| 2021(7)： |
| 1. Zhang, Ge; Song, Yi-Kang; Zhang, Fang; Xue, Ze-Jian; Li, Meng-Yao; Zhang, Gui-Shan; Zhu, Bin-Bin; Wei, Jing; Li, Chunsen; Feng, Chen-Guo; Lin, Guo-Qiang Palladium-Catalyzed Allene Synthesis Enabled by Beta-Hydrogen Elimination from Sp2-Carbon. Nature communications 2021, 12, 728-728. |
| 2. Zhang, Ge; Li, Meng-Yao; Ye, Wen-Bo; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang Borylation of Unactivated C(Sp(3))-H Bonds with Bromide as a Traceless Directing Group. Org. Lett. 2021, 23, 2948-2953. |
| 3. Xue, Ze-Jian; Li, Meng-Yao; Zhu, Bin-Bin; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang A 1,4-Palladium Migration/Heck Sequence with Unactivated Alkenes: Stereoselective Synthesis of Trisubstituted 1,3-Dienes. Adv. Synth. Catal. 2021, 363, 2089-2092. |
| 4. Xu, Si-Yu; Zhang, Rui; Zhang, Shu-Sheng; Feng, Chen-Guo Enantioselective Synthesis of 3-Aryl-Phthalides through a Nickel-Catalyzed Stereoconvergent Cross-Coupling Reaction. Organic & Biomolecular Chemistry 2021, 19, 4492-4496. |
| 5. Tian, Tian; Zhou, Bo-wen; Wu, Li-hong; Zhang, Fang; Chou, Gui-xin; Feng, Chen-guo; Lin, Guo-qiang Non-Targeted Screening of Pyranosides in Rhodiola Crenulata Using an All Ion Fragmentation-Exact Neutral Loss Strategy Combined with Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Phytochem. Anal 2021. |
| 6. Song, Yi-Kang; Xu, Si-Yu; Zhang, Shu-Sheng; Fu, Jian-Guo; Lin, Guo-Qiang; Feng, Chen-Guo Palladium-Catalyzed Tandem Gamma-Arylation/Aromatization of Cyclohex-2-En-1-One Derivatives: A Route to 3,4-Dihydroanthracen-1(2h)-Ones. Adv. Synth. Catal. 2021, 363, 3001-3005. |
| 7. Song, Yi-Kang; Liu, Li; Wang, Jun-Jie; Qian, Fei; Yang, Mao-Qi; Zhang, Liu-Qiang; Fu, Jian-Guo; Li, Yi-Ming; Feng, Chen-Guo An Asymmetric Synthesis of (+)-Scrodentoid a from Dehydroabietic Acid. Tetrahedron 2021, 85, 132031. |
| 2020(3)： |
| 1. Zhang, Ge; Fu, Jian-Guo; Zhao, Qian; Zhang, Gui-Shan; Li, Meng-Yao; Feng, Chen-Guo; Lin, Guo-Qiang Silver-Promoted Synthesis of Vinyl Sulfones from Vinyl Bromides and Sulfonyl Hydrazides in Water. Chem. Commun. 2020, 56, 4688-4691. |
| 2. Xue, Ze-Jian; Li, Meng-Yao; Zhu, Bin-Bin; He, Zhi-Tao; Feng, Chen-Guo; Lin, Guo-Qiang Stereoselective Synthesis of Conjugated Trienes Via 1,4-Palladium Migration/Heck Sequence. Chem. Commun. 2020, 56, 14420-14422. |
| 3. Li, Meng-Yao; Han, Pengbo; Hu, Tian-Jiao; Wei, Dong; Zhang, Ge; Qin, Anjun; Feng, Chen-Guo; Tang, Ben Zhong; Lin, Guo-Qiang Suzuki-Miyaura Coupling Enabled by Aryl to Vinyl 1,4-Palladium Migration. Iscience 2020, 23, 100966. |
| 2019(5)： |
| 1. Zhou, Jing; Zhang, Hong; Chen, Xue-Lian; Qu, Ya-Li; Zhu, Qianqian; Feng, Chen-Guo; Chen, Ya-Jing Regio- and Diastereoselective Access to 4-Imidazolidinones Via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic Imines with Alpha-Halo Hydroxamates. J. Org. Chem. 2019, 84, 9179-9187. |
| 2. Zhang, Shu-Sheng; Hu, Tian-Jiao; Li, Meng-Yao; Song, Yi-Kang; Yang, Xiao-Di; Feng, Chen-Guo; Lin, Guo-Qiang Asymmetric Alkenylation of Enones and Imines Enabled by a Highly Efficient Aryl to Vinyl 1,4-Rhodium Migration. Angew. Chem. Int. Ed. 2019, 58, 3387-3391. |
| 3. Zhang, Ge; Bai, Rui-Xue; Li, Chu-Han; Feng, Chen-Guo; Lin, Guo-Qiang Halogenation of 1,1-Diarylethylenes by N-Halosuccinimides. Tetrahedron 2019, 75, 1658-1662. |
| 4. Wei, Dong; Li, Meng-Yao; Zhu, Bin-Bin; Yang, Xiao-Di; Zhang, Fang; Feng, Chen-Guo; Lin, Guo-Qiang Sequential Cross-Coupling/Annulation of Ortho-Vinyl Bromobenzenes with Aromatic Bromides for the Synthesis of Polycyclic Aromatic Compounds. Angew. Chem. Int. Ed. 2019, 58, 16543-16547. |
| 5. Lv, Shao-Dong; Tian, Tian; Zhang, Liu-Qiang; Xu, Si Yu; Zhao, Dong-Hai; Wang, Jun-Jie; Fu, Jian-Guo; Li, Yi-Ming; Feng, Chen-Guo Total Synthesis of (+/-)-Scrodentoid A. Tetrahedron 2019, 75, 130774-130775. |
| 2018(4)： |
| 1. Wei, Dong; Hu, Tian-Jiao; Feng, Chen-Guo; Lin, Guo-Qiang Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes. Chin. J. Chem . 2018, 36, 743-748. |
| 2. Meng, Jiao-Long; Jiao, Tang-Qian; Chen, Ya-Heng; Fu, Rui; Zhang, Shu-Sheng; Zhao, Qian; Feng, Chen-Guo; Lin, Guo-Qiang Synthesis of Chiral Isoindolinones Via Asymmetric Propargylation/Lactamization Cascade. Tetrahedron Lett. 2018, 59, 1564-1567. |
| 3. Hu, Tian-Jiao; Li, Meng-Yao; Zhao, Qian; Feng, Chen-Guo; Lin, Guo-Qiang Highly Stereoselective Synthesis of 1,3-Dienes through an Aryl to Vinyl 1,4-Palladium Migration/Heck Sequence. Angew. Chem. Int. Ed. 2018, 57, 5871-5875. |
| 4. Ge, Yao; Han, Zhaobin; Wang, Zheng; Feng, Chen-Guo; Zhao, Qian; Lin, Guo-Qiang; Ding, Kuiling Ir-Spinphox Catalyzed Enantioselective Hydrogenation of 3-Ylidenephthalides. Angew. Chem. Int. Ed. 2018, 57, 13140-13144. |
| 2017(1): |
| 1. Qian, Xue-Wei; Xue, Ze-Jian; Zhao, Qian; Cui, Zhe; Chen, Ya-Jing; Feng, Chen-Guo; Lin, Guo-Qiang Enantioselective Rhodium-Catalyzed Alkenylation of Aliphatic Lmines. Org. Lett. 2017, 19, 5601-5604. |
| 2016(1): |
| 1. Hu, T. J.; Zhang, G.; Chen, Y. H.; Feng, C. G.; Lin, G. Q. Borylation of Olefin C-H Bond Via Aryl to Vinyl Palladium 1,4-Migration. J. Am. Chem. Soc. 2016, 138, 2897-2900. |
| 2015(3): |
| 1. Dong, Han-Qing; Xu, Ming-Hua; Feng, Chen-Guo; Sun, Xing-Wen; Lin, Guo-Qiang Recent Applications of Chiral N-Tert-Butanesulfinyl Imines, Chiral Diene Ligands and Chiral Sulfur–Olefin Ligands in Asymmetric Synthesis. Org. Chem. Front. 2015, 2, 73-89. |
| 2. Chen, Y. J.; Hu, T. J.; Feng, C. G.; Lin, G. Q. Synthesis of Chiral Cyclobutanes Via Rhodium/Diene-Catalyzed Asymmetric 1,4-Addition: A Dramatic Ligand Effect on the Diastereoselectivity. Chem. Commun. 2015, 51, 8773-8776. |
| 3. Chen, Y. J.; Cui, Z.; Feng, C. G.; Lin, G. Q. Enantioselective Addition of Heteroarylboronates to Arylimines Catalyzed by a Rhodium-Diene Complex. Adv. Synth. Catal. 2015, 357, 2815-2820. |
| 2014(2): |
| 1. Cui, Z.; Chen, Y. J.; Gao, W. Y.; Feng, C. G.; Lin, G. Q. Enantioselective Alkenylation of Aldimines Catalyzed by a Rhodium-Diene Complex. Org. Lett. 2014, 16, 1016-1019. |
| 2. Chen, Y. J.; Chen, Y. H.; Feng, C. G.; Lin, G. Q. Enantioselective Rhodium-Catalyzed Arylation of Cyclic N-Sulfamidate Alkylketimines: A New Access to Chiral Beta-Alkyl-Beta-Aryl Amino Alcohols. Org. Lett. 2014, 16, 3400-3403. |
| 2013(2): |
| 1. Miura, M.; Feng, C. G.; Ma, S.; Yu, J. Q. Pd(Ii)-Catalyzed Ortho-Trifluoromethylation of Benzylamines. Org. Lett. 2013, 15, 5258-5261. |
| 2. Feng, C. G.; Ye, M. C.; Xiao, K. J.; Li, S. H.; Yu, J. Q. Pd(Ii)-Catalyzed Phosphorylation of Aryl C-H Bonds. J. Am. Chem. Soc. 2013, 135, 9322-9325. |
| 2012(3): |
| 1. Yu, Hong-Jie; Shao, Cheng; Cui, Zhe; Feng, Chen-Guo; Lin, Guo-Qiang Highly Enantioselective Alkenylation of Cyclic Alpha,Beta-Unsaturated Carbonyl Compounds as Catalyzed by a Rhodium-Diene Complex: Application to the Synthesis of (S)-Pregabalin and (-)-Alpha-Kainic Acid. Chemistry-a European Journal 2012, 18, 13274-13278. |
| 2. Shao, Cheng; Yu, Hong-Jie; Feng, Chen-Guo; Wang, Rui; Lin, Guo-Qiang Easily Accessible Chiral Dicyclopentadiene Ligands for Rhodium-Catalyzed Enantioselective 1,4-Addition Reactions. Tetrahedron Lett. 2012, 53, 2733-2735. |
| 3. He, Zhi-Tao; Wei, Ya-Bing; Yu, Hong-Jie; Sun, Cai-Yun; Feng, Chen-Guo; Tian, Ping; Lin, Guo-Qiang Rhodium/Diene-Catalyzed Asymmetric Arylation of N-Boc-Protected Alpha,Beta-Unsaturated Delta-Lactam with Arylboronic Acids: Enantioselective Synthesis of 4-Aryl-2-Piperidinones. Tetrahedron 2012, 68, 9186-9191. |
| 2011(3): |
| 1. Shao, Cheng; Yu, Hong-Jie; Wu, Nuo-Yi; Tian, Ping; Wang, Rui; Feng, Chen-Guo; Lin, Guo-Qiang Asymmetric Synthesis of Beta-Substituted Gamma-Lactams Via Rhodium/Diene-Catalyzed 1,4-Additions: Application to the Synthesis of (R)-Baclofen and (R)-Rolipram. Org. Lett. 2011, 13, 788-791. |
| 2. Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang Development of Bicyclo 3.3.0 Octadiene-or Dicyclopentadiene-Based Chiral Diene Ligands for Transition-Metal-Catalyzed Reactions. Synlett 2011, 1345-1356. |
| 3. Cui, Zhe; Yu, Hong-Jie; Yang, Rui-Feng; Gao, Wen-Yun; Feng, Chen-Guo; Lin, Guo-Qiang Highly Enantioselective Arylation of N-Tosylalkylaldimines Catalyzed by Rhodium-Diene Complexes. J. Am. Chem. Soc. 2011, 133, 12394-12397. |
| 2010(2): |
| 1. Wang, Zhi-Qian; Feng, Chen-Guo; Zhang, Shu-Sheng; Xu, Ming-Hua; Lin, Guo-Qiang Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo 3.3.0 Diene Ligands. Angew. Chem. Int. Ed. 2010, 49, 5780-5783. |
| 2. Shao, Cheng; Yu, Hong-Jie; Wu, Nuo-Yi; Feng, Chen-Guo; Lin, Guo-Qiang C-1-Symmetric Dicyclopentadienes as New Chiral Diene Ligands for Asymmetric Rhodium-Catalyzed Arylation of N-Tosylarylimines. Org. Lett. 2010, 12, 3820-3823. |
| 2008(4): |
| 1. Zhou, Jing; Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang; Guo, Yinlong Study on Mass Spectrometric Behavior of Samarium Di-Iodide in Tetrahydrofuran Solution. Int. J. Mass spectrom. 2008, 270, 62-67. |
| 2. Liu, G.; Meng, J.; Feng, C. G.; Huang, P. Q. Asymmetric Syntheses of (-)-Epi-Pseudoconhydrine and (-)-5-Hydroxysedamine Based on a Cis-Diastereoselective 1,4-Asymmetric Induction. Tetrahedron-Asymmetr 2008, 19, 1297-1303. |
| 3. Feng, Chen-Guo; Wang, Zhi-Qian; Tian, Ping; Xu, Ming-Hua; Lin, Guo-Qiang Easily Accessible C2-Symmetric Chiral Bicyclo[3.3.0] Dienes as Ligands for Rhodium-Catalyzed Asymmetric 1,4-Addition. Chemistry-an Asian Journal 2008, 3, 1511-1516. |
| 4. Feng, Chen-Guo; Wang, Zhi-Qian; Shao, Cheng; Xu, Ming-Hua; Lin, Guo-Qiang Highly Practical Catalytic Asymmetric 1,4-Addition of Arylboronic Acids in Water Using New Hydrophilic Chiral Bicyclo[3.3.0] Diene Ligands. Org. Lett. 2008, 10, 4101-4104. |
| 2007(1): |
| 1. Wang, Zhi-Qian; Feng, Chen-Guo; Xu, Ming-Hua; Lin, Guo-Qiang Design of C-2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids. J. Am. Chem. Soc. 2007, 129, 5336-+. |
| 2006(1): |
| 1. Feng, C. G.; Chen, J.; Ye, J. L.; Ruan, Y. P.; Zheng, X.; Huang, P. Q. Syntheses of Enantio-Enriched Chiral Building Blocks from L-Glutamic Acid. Tetrahedron 2006, 62, 7459-7465. |
| 2005(1): |
| 1. Zheng, X.; Feng, C. G.; Ye, J. L.; Huang, P. Q. Samarium Diiodide Promoted Generation and Asymmetric Hydroxyalkylation of N,O-Diprotected (3s)-3-Pyrrolidinol 2-Carbanions. Org. Lett. 2005, 7, 553-556. |