| 姓名： | 贺庆利 | 性别： | 男 |
| 职称： | 研究员 | 学历： | 博士研究生 |
| 专家类别： | 博导 | 职务： | |
| 电话： | 021-51322673 | 传真： | |
| 电子邮箱： | qinglihe@shutcm.edu.cn | ||
| 通讯地址： | 上海市浦东新区蔡伦路1200号 | ||
| 个人主页： | |||
招生专业：
| 院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
| 创新中药研究院 | 理学 | 中药学 | 100800/中药学 | 学术型 | 硕、博士 |
个人简历：
| 2017年-目前 | 研究员，上海市中医药大学，创新中药研究院，手性药物研究中心 |
| 2016年 | Research Scientist，阿肯色大学化学和生物化学系 |
| 2009-2016年 | Postdoctoral Fellow，约翰霍普金斯大学药理和分子科学系（导师：Jun O Liu） |
| 2002-2008年 | 博士，上海有机化学研究所，有机化学专业（导师：唐功利和刘文研究员） |
| 1998-2002年 | 本科，山东大学，化学专业 |
研究内容：
| 天然产物的药物作用机理研究和新药研发 |
| 中药活性成分的合成生物学研究和微生物发酵研究 |
学术荣誉：
| 上海市教育委员会上海市高校特聘教授（东方学者） 2018 |
主持科研项目：
| 课题名称 | 项目名称 | 起止时间 | 金额 |
| 中药活性成分的药物作用机理和生物合成研究 | 上海市教育委员会“东方学者”项目 | 2019.01-2021.12 | 100万 |
| 人工修饰材料用于智能钓取中药分子合成酶 | 上海市科技委员会“探索类”基金 | 2019.07-2022.06 | 20万 |
发表文章：
| 1. Qiang Zhou#, Shu-Ya Peng#, Kai Zhang, Guang-Cai Luo, Li Han, Qing-Li He*, and Gong-Li Tang* A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin. Org. Lett. 2021. 23(6):2342-2346 (IF: 6.1) |
| 2. Lu Tong#, Qunfei Zhao#, Emmanuel Datan, Guo-Qiang Lin, Daniel Romo, Biao Yu, Qing-Li He*, Jun O Liu* Triptolide: Reflections on Two Decades of Research and Prospects for the Future，Nat. Prod. Rep.，2021, 38, 843-860 （IF: 12.0） |
| 3. Emmanuel Datan#, Il Minn#, Peng Xu#, Qing-Li He, Hye-Hyun Ahn, Biao Yu, * Martin G. Pomper,* Jun O. Liu,* A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia, Iscience, 2020, 23(9):101536 (IF: 4.4) |
| 4. Xuan Yi#, Qunfei Zhao#, Zhenhua Tian, Xinying Jia, Weiguo Cao, Wen, Liu*, Qing-Li He *. Insights into the Functionalization of the Methylsalicyclic Moiety during the Biosynthesis of Chlorothricin by Comparative Kinetic Assays of the Activities of Two KAS III-like Acyltransferases，Chin. J. Chem., 2019, 37: 821-826 （IF: 3.8） |
| 5. The biosynthesis of diterpenoids from plants，Xuan Yi, Qing-Li He* , Wen Liu*, Chin. Bull. Life Sci., 2019, 31(5)， 458-472 |
| 6. Zhi Lin#, Qingli He#, and Wen Liu* Bio-Inspired Engineering of Thiopeptide Antibiotics Advances the Expansion of Molecular Diversity and Utility. Curr. Opin. Biotechnol. 2017, 48, 210-219 (IF：9.3) |
| 7. Qing-Li He#, IL Minn#, Qiaoling Wang, Peng Xu, Biao Yu, Martin Pomper*, Jun O Liu* Targeted delivery and sustained antitumor activity of triptolide through glucose conjugation. Angew. Chem. Int. Ed. 2016, 55, 12035-12039 (Science Daily, 2016, Sept 7) (IF: 12.0) |
| 8. Qing-Li He#, Denis V. Titov#, Jing Li, Minjia Tan, Zhaohui Ye, Yingming Zhao, Daniel Romo, and Jun O. Liu* Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide. Angew. Chem. Int. Ed. 2015, 54, 1859 –1863 (IF: 12.0) |
| 9. Minghua Wang, Joong Sup Shim, Ruo-Jing Li, Yongjun Dang, Qingli He, Manisha Das and Jun O Liu*. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Br. J. Pharmacol. 2014, 171(19), 4478-4489 (IF: 5.5) |
| 10. Hui Xu#, Wei Huang#, Qing-Li He, Zhi-Xiong Zhao, Feng Zhang, Renxiao Wang, Jingwu Kang,and Gong-Li Tang*. Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis. Angew. Chem. Int. Ed. 2012, 51, 10532 –10536 (Highlighted by Nature Chemical Biology, 2012, 8, 873) (IF: 12.0) |
| 11. Wei Huang#, Hui Xu#, Yan Li, Feng Zhang, Xin-Ya Chen, Qing-Li He, Yasuhiro Igarashi, and Gong-Li Tang*. Characterization of Yatakemycin Gene Cluster Revealing a Radical S-adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis. J. Am. Chem. Soc. 2012, 134, 8831−8840 (Highlighted in Hot of the press Nat. Prod. Rep. 2012, 29, 829-833) (IF: 13.9) |
| 12. Supakarn Chamni, Qing-Li He, Yongjun Dang, Shridhar Bhat, Jun O. Liu, and Daniel Romo*. Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural Products via O-H Insertion. ACS Chemical Biology, 2011, 6, 1175-1181(IF: 5.0) |
| 13. Denis V. Titov, Benjamin Gilman, Qing-Li He, Shridhar Bhat, Woon-Kai Low, Yongjun Dang, Michael Smeaton, Arnold J. Demain, Paul S. Miller, Jennifer F. Kugel, James A. Goodrich, Jun O. Liu*, XPB, a Subunit of TFIIH, Is a Target of the Natural Product Triptolide, Nat. Chem. Biol., 2011, 7, 182-188 (Highlighted by Chemical & Engineering News. 2011 89(5) 45, and Science Daily 2011, Mar. 3) (IF: 15.1) |
| 14. Jun O. Liu*, Denis V. Titov, Yongjun Dang, Qingli He, Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP, Mol. Cell, 2011, 41, 131-133(IF: 14.7) |
| 15. Wei Ding, Chun Lei, Qingli He, Qinglin Zhang, Yurong Bi, and Wen Liu* Insights into Bacterial 6-Methylsalicylic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Spirotetronate Generation, Chem. & Biol. 2010, 17, 495–503(IF: 6.7) |
| 16. Feng-Lai Sun, Xiao-Jian Zheng, Qing Gu, Qing-Li He, and Shu-Li You*, Enantioselective Synthesis of Unsymmetrical Triarylmethanes by Chiral Brønsted Acids, Eur. J. Org. Chem. 2010, 47–50(IF: 2.8) |
| 17. Qing-Li He, Feng-Lai Sun, Xiao-Jian Zheng, Shu-Li You*, Brønsted Acid Catalyzed Synthesis of Unsymmetrical Arylbis(3-indolyl)-methanes, Synlett , 2009, 7, 1111–1114(IF: 2.2) |
| 18. Yi Li, Fu-Qiang Shi, Qing-Li He and Shu-Li You*, N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aldehydes with Arylsulfonyl Indoles, Org. Lett. 2009, 11 (15), 3182–3185(IF: 6.6) |
| 19. Qing-Li He, Xin-Ying Jia, Man-Cheng Tang, Zhen-Hua Tian, Gong-Li Tang*, and Wen Liu*, Dissection of Two Acyl Transfer Reactions Centered on Acyl-S-Carrier Protein Intermediates for Incorporating 5-chloro-6-methyl-O-methylsalicyclic Acid into Chlorothricin, ChemBioChem , 2009, 10, 813 – 819(IF: 2.8) |
| 20. Mi Zeng, Qiang Kang, Qing-Li He and Shu-Li You*, Highly Enantioselective Friedel-Crafts Reaction of 4,7-Dihydroindoles with β,γ-Unsaturated α-Keto Esters by Chiral Brønsted Acids, Adv. Synth. & Catal. 2008, 350, 2169-2173 (IF: 5.6) |
| 21. Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang, and Wen Liu*, Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis, Chem. & Biol. 2008, 15, 693–705（Highlighted by Nat. China 2008, Doi:10.1038/nchina.2008.196，Antibiotic biosynthesis: from Genes to Enzymes.）(IF: 6.7) |
| 22. Qing-Li He, Hui Jiang, Feng Zhang, Hai-Bao Chen, Gong-Li Tang*, Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning, Bioorg. & Med. Chem. Lett. 2008, 18, 3995–3998(IF: 2.5) |
专利：
| 1. Jun O Liu, Qing-Li He, Martin Pomper, IL Minn, Biao Yu, Qiaoling Wang. GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF. U United States Patent No .: US 10,695,319 B2 and PCT Application No. US2017/016527 |