赵群飞

发布者:创新中药1发布时间:2021-04-25浏览次数:2325

姓名:赵群飞性别:
职称:研究员学历:博士研究生
专家类别:硕导职务:
电话:
传真:
电子邮箱:qunfeizhao@shutcm.edu.cn
通讯地址:上海市浦东新区蔡伦路1200号
个人主页:

招生专业:

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
创新中药研究院理学中药学100800/中药学学术型硕士

个人简历:

2024.01-至今研究员,上海中医药大学,创新中药研究院,手性药物研究中心
2018.03-2023.12
副研究员,上海中医药大学,创新中药研究院,手性药物研究中心
2012.06-2018.03副研究员,中科院上海有机化学研究所,生命有机化学国家重点实验室
2006.03-2012.06助理研究员,中科院上海有机化学研究所,生命有机化学国家重点实验室
2003.07-2006.03研究实习员,中科院上海有机化学研究所,生命有机化学国家重点实验室
2000.09-2003.07硕士,华东师范大学,生命科学学院,生物化学与分子生物学专业
2009.09-2013.06本科,华东师范大学,生物系

研究内容:

中药源活性分子的生物合成研究
合成生物学技术挖掘珍稀药用真菌活性分子

学术奖项:

上海市自然科学一等奖 2019年

主持科研项目:

课题名称项目名称起止时间金额

药用真菌乌灵参生境依赖性活性分子的挖掘和生物合成机制研究

国家自然科学基金面上项目2024.1-2017.1249万
轴手性蒽醌二聚体骨架结构天然产物的生物合成研究国家自然科学基金面上项目 2020.1-2023.1266万
合成生物学理念指导新型硫肽类抗生素的研制上海市科委“科技创新行动计划”基础重点项目2017.9-2020.880万
合成生物学精准构筑轴手性蒽醌二聚体类天然产物上海市手性药物分子工程重点实验室开放课题2021.01-2022.126万
轴手性蒽醌二聚体类化合物Phlegmacin的生物合成研究生命有机化学国家重点实验室开放基金2020.1-2022.125万
林可霉素正丙基脯氨酸结构单元生物合成机制研究及工业生产菌株的代谢工程改造国家自然科学基金青年科学基金项目2014.1-2016.1223万
微生物药物高效合成生物技术研究与应用科技部863”项目子课题2012.1-2015.1293万

代表性论文:

1. Zhuo-Zheng Xu, Zheng Zhuang, Runlin Cai, Guo-Qiang Lin, Zhigang She*, Qunfei Zhao* and Qing-Li He*. Hydroxylation with Unusual Stereoinversion Catalyzed by an FeII/2-OG Dependent Oxidase and 3,6-Diene-2,5-diketopiperazine Formation in the Biosynthesis of Brevianamide K, Angewandte Chemie International Edition, 2023, 62(14): e202216989.
2. Jia-Yu Shen, Qunfei Zhao* and Qing-Li He*. Application of CRISPR in Filamentous Fungi and Macrofungi: From Component Function to Development Potentiality. ACS Synthetic Biology, 2023, 12(7): 1908-23.
3. Zheng Zhuang, Xueqing Zhong, Qinghua Li, Tian Liu, Qing Yang, Guo‑Qiang Lin, Qing‑Li He*, Qunfei Zhao* and Wen Liu, Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment, Bioresources and Bioprocessing, 2023, 10: 2.
4. An-An Zhang, Qing-Li He* and Qunfei Zhao*. Mining and Characterization of Indolethylamine N-Methyltransferases in Amphibian Toad Bufo gargarizans. Biochemistry 2023, 62(16):2371-2381
5. Pei-Pei Ou, Qing-Li He* and Qunfei Zhao*. Structural diversification of natural substrates modified by the O-methyltransferase AurJ from Fusarium Graminearum. Biochemical and Biophysical Research Communications 2023, 678: 158–164.
6. Qunfei Zhao, Zheng Zhuang, Tian Liu, Qing Yang*, Qing-Li He*, Wen Liu*, and Guo-Qiang Lin*. Unsymmetrically Regioselective Homodimerization Depends on the Subcellular Co-localization of Laccase/Fasciclin Protein in the Biosynthesis of Phlegmacins. ACS Chemical Biology, 2022, 17(4):791-796.
7. Ming Chen, Bo Pang, Wenping Ding, Qunfei Zhao*, Zhijun Tang*, Wen Liu*. Investigation of 2,2’-Bipyridine Biosynthesis Reveals a Common Two-Component System for Aldehydes Production by Carboxylate Reduction. Organic Letters, 2022, 24(3): 897-902.
8. Lu Tong#, Qunfei Zhao#, Emmanuel Datan, Guo-Qiang Lin, Il Minn, Martin G Pomper, Biao Yu, Daniel Romo, Qing-Li He*, Jun O Liu*.Triptolide: reflections on two decades of research and prospects for the future. Natural Product Reports 2021,38(4),843-860.
9. Xuan Yi#, Qunfei Zhao#, Zhenhua Tian, Xinying Jia, Weiguo Cao, Wen Liu*, Qing-Li He*. Insights into the Functionalization of the Methylsalicyclic Moiety during the Biosynthesis of Chlorothricin by Comparative Kinetic Assays of the Activities of Two KAS III‐like Acyltransferases. Chinese J. Chem. 2019, 37(8),821-826.
10. Dandan Chen#; Qunfei Zhao#, Wen Liu*. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J. Ind. Microbiol. Biot. 2019, 46:459-468.
11. Guannan Zhong, Qunfei Zhao, Qinglin Zhang, Wen Liu*. , 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage. Nat. Commun. 2017, 8, 16109.
12. Min Wang, Qunfei Zhao*, Qinglin Zhang, Wen Liu*, Differences in PLP-Dependent Cysteinyl Processing Lead to Diverse S‑Functionalization of Lincosamide Antibiotics. J. Am. Chem. Soc. 2016, 138, 6438-6351.
13. Min Wang#, Qunfei Zhao#, Wen Liu*. The versatile low-molecular-weight thiols: Beyond cell protection. Bioessays 2015, 37(12): 1262-1267. 
14. Qunfei Zhao#, Min Wang#, Dongxiao Xu, Qinglin Zhang, Wen Liu*. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. Nature 2015, 518, 115-119. (Featured in:  Nature 2015, 518, 45-46; Natl. Sci. Rev. 2015, 2, 382–384; F1000Prime 2015, doi: 10.3410/f.725320497.793503602 and doi: 10.3410/f.725320497.793503765)
15. Peng Sun, Qunfei Zhao, Futao Yu, Hua Zhang, Zhuhua Wu, Yinyan Wang, Yan Wang, Qinglin Zhang, Wen Liu*. Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. J. Am. Chem. Soc. 2013, 135 (4), 1540-1548. Hot off the press. Nat. Prod. Rep. 2013)
16. Qunfei Zhao, Qing-Li He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gong-Li Tang, Wen Liu*. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem. Biol. 2008, 15(7), 693-705. (Featured in: Nat. China 2008, Doi: 10.1038/nchina.2008.196) 

专著章节:

1. 赵群飞,陈单丹,刘文,第二十章:靶向细胞信号转导的天然产物生物合成路径与机制。小分子探针与信号转导,张礼和,陈拥军等,科学出版社,2020,P507-530

获授权专利:

1. 林国强、叶文博、赵群飞、张建革、贺庆利、王超,一种天然蟾毒基内酯类化合物的制备方法,专利号:ZL 2022 1 0129037.9
2. Liu, W., Zhao, Q., Xu, D., Zhang, Q., Lincomycin biosynthetic intermediates, method for preparation, and use thereof, Patent No:US10,590,159 B2
3. 刘文、赵群飞、王敏,林可霉素生物合成中间产物及其制法和用途,专利号:ZL 2014 1 0625571.4
4. 刘文、赵群飞,一种阿维菌素产生菌及其制备方法和应用,专利号:ZL 2012 1 0477320.7
5. 刘文、赵群飞、张华、董坤、彭欣、李慧芬,一种泰乐菌素产生菌、遗传改造方法及其应用,专利号:ZL 2012 1 0517193.9
6. 刘文、赵群飞,阿嗪霉素的生物合成基因簇,专利号:ZL 2008 1 0034378.8