高顶顶

第一作者或者通讯作者发表的文章

2024年

(1)  Feng Wang^#, Donglan Liu^#, Dingding Gao*, Jinwei Yuan, Jingxian Zhao, Shuai Yuan, Yixin Cen*, Guo-Qiang Lin*, Jincun Zhao*, Ping Tian*. Discovery of natural catechol derivatives as covalent SARS-CoV-2 3CLpro inhibitors. Int J Biol Macromol.2024, 264, 130377.

(2)  Xin-Yu Cao^#, Xinge Li^#, Feng Wang^#, Yichen Duan, Xingmei Wu, Guo-Qiang Lin, Meiyu Geng, Min Huang, Ping Tian*, Shuai Tang*, Dingding Gao*. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg. Chem. 2024, 146, 107330.

2023年

(1) Fu-Mao Zhang^#, Ting Huang^#, Feng Wang^#, Gui-Shan Zhang, Donglan Liu, Jun Dai, Jian-Wei Zhang, Qing-Hua Li, Guo-Qiang Lin, Dingding Gao*, Jincun Zhao*, Ping Tian*. Eur J Med Chem.2023, 260, 115721.

(2) Qing-Hua Li^#, Gui-Shan Zhang^#, Feng Wang, Yixin Cen, Xi-Liang Liu, Jian-Wei Zhang, Yu-Hui Wang*, Albert W. M. Lee*, Dingding Gao*, Guo-Qiang Lin, Ping Tian*. Nature-inspired catalytic asymmetric rearrangement of cyclopropylcarbinyl cation. Sci. Adv.2023, 9, eadg1237.

(3) Jia-Ying Zhao^#, Qi Liao^#, Jian-Wei Zhang, Guo-Qiang Lin, Zheng-Tao Wang*, Dingding Gao*, Qing-Hua Li*, and Ping Tian*. Thiourea-Promoted Cascade Dihalogenation-Cyclization of Cyclohexadienone-Containing 1,6-Enynes. Adv. Synth. Catal.2023, 365, 1 –9.

(4) Dingding Gao^{*, #}, Shuai Tang^#, Yixin Cen^#, Liang Yuan, Xiaojing Lan, Qing-Hua Li,* Guo-Qiang Lin, Min Huang,* and Ping Tian*. Discovery of novel drug-like PHGDH inhibitors to disrupt serine biosynthesis for cancer therapy.J. Med. Chem.,2023, 66, 285–305.

2022年

(1) Feng Wang, Xin-Yu Cao, Guo-Qiang Lin, Ping Tian*, Dingding Gao*. Novel inhibitors of the STAT3 signaling pathway: an updated patent review (2014-present). Expert Opin. Ther. Pat. 2022, 32, 667−688.

(2) Fu-Mao Zhang^#, Liang Yuan^#, Xin-Wei Shi^#, Kai-Rui Feng, Xiaojing Lan, Cheng Huang, Guo-Qiang Lin, Ping Tian, Min Huang, Shuai Tang*, Dingding Gao*. Discovery of PHGDH inhibitors by virtual screening and preliminary structure–activity relationship study. Bioorg. Chem. 2022, 121, 105705.

(3) Jian-Wei Zhang^#, Yuan Xiong^#, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo-Qiang Lin, Ping Tian*, Guangbo Ge*, Dingding Gao*. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL^pro inhibitors for treating COVID-19. Eur. J. Med. Chem.,2022, 228, 114030.

2021年

(1) Yun-Xuan Tan, Pei-Ying Peng, Ya-Jie Wang, Xi-Liang Liu, Wenbo Ye,* Dingding Gao*, Guo-Qiang Lin, and Ping Tian*, Diastereo- and enantioselective rhodium(III)-catalyzed reductive cyclization of cyclohexadienone-containing 1,6-dienes. Chem. Commun.2021, 57, 9724−9727.

(2) Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng*, Guo-Qiang Lin, Dingding Gao*, Ping Tian*. A Retrospective Overview of PHGDH and Its Inhibitors for Regulating Cancer Metabolism. Eur. J. Med. Chem.,2021, 217, 113379.

(3) Dingding Gao^#, NanJin^#, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, QiangXiao, Min Huang, Yingxia Li*. Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. Eur. J. Med. Chem.,2021, 216, 113333.

2020年

(1) Cheng-Yu He^#, Yun-Xuan Tan^#, Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao^*, Ping Tian ^*, Guo-Qiang Lin^*. Copper(I)-Catalyzed Diastereo- and Enantioselective Construction of Optically Pure Exocyclic Allenes. Nat. Commun.2020,11, 4293.

(2) Qing-Hua Li^#,Dingding Gao^#, Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian*. One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization. Cell Reports Physical Science 2020, 1, 100222.

(3) Dingding Gao^#,Xing-Yu Liu^#, Hao Xu^#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li^*, Xiaodi Yang, Guo-Qiang Lin^*, and Ping Tian^*. One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 2020, 22, 4300−4305.

(4) Kai-Rui Feng^#, Feng Wang^#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li^*, Guo-Qiang Lin, Dingding Gao^*, and Ping Tian^*. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem.,2020, 201, 112428.

(5) Dingding Gao⁺, Feng Wang⁺, Xing-Yu Liu, Kai-Rui Feng, Jia-Ying Zhao, Yu-Hui Wang*, Xiao-Di Yang*, Ping Tian*, and Guo-Qiang Lin. Synthesis of Decahydrocyclobuta[cd]indene Skeleton: Rhodium(III)-Catalyzed Hydroarylaton and Relay Thiophene-Promoted Intramolecular [2 + 2] Cycloaddition. Adv. Synth. Catal.2020, 362, 4384–4390.

(6) Jun-Li Zhang^#, Dingding Gao^#, Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li*, Ping Tian*. Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 2020, 22, 3661-3666.

(7) Ming-Shun Mei^#, Yu-Hui Wang^#, Qing Hu, Qing-Hua Li,Da-Yu Shi, Dingding Gao*, Guangbo Ge,* Guo-Qiang Lin, and Ping Tian*.Enantioselective [3 + 2] Annulation of Isatin-Derived MBH-Carbonates and 3-Nitroindoles Enabled by a Bifunctional DMAP-Thiourea. Chem. Commun.2020, 56, 10718-10721.

(8) Feng Wang^#, Kai-Rui Feng^#, Jia-Ying Zhao, Jian-Wei Zhang, Xin-Wei Shi, Jian Zhou*, Dingding Gao *, Guo-Qiang Lin, and Ping Tian*. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study.Bioorg. Med. Chem. 2020, 28, 115822.

2019年以前

(1) Bingbing Zhang^#, Jiami Liu^#, Dingding Gao^#, Xiaolin Yu, Jinlei Wang, Xinsheng, Lei^*. A fluorine scan on the Zn²⁺-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling. Eur. J. Med. Chem., 2019, 182, 111672.

(2) Yulong He^#, Huixia Dou^#, Dingding Gao^#, Ting Wang, Mingming Zhang^*, Heyao Wang^*, Yingxia Li^*. Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor. Bioorg. Med. Chem., 2019, 27, 115015.

(3) Dingding Gao^#, Huixia Dou^#, Haixia Su^#, Mingming Zhang^#, Ting Wang, Qiufeng Liu, Haiyan Cai, Zhuo Yang, Weiliang Zhu^*, Yechun Xu^*, Heyao Wang^*, Yingxia Li^*. From Hit to Lead: Structure-based Discovery of Naphthalene-1-Sulfonamide Derivatives as Potent and Selective Inhibitors of Fatty Acid Binding Protein 4. Eur. J. Med. Chem., 2018, 154, 44-59.

(4) Dingding Gao, Yingxia Li*. Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg. Med. Chem., 2017, 25, 3780-3791.

(5) Jing Cui^#, Xia Peng^#, Dingding Gao^#, Yang Dai, Jing Ai*, Yingxia Li*. Optimization of 1H -indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors. Bioorg. Med. Chem. Lett.,2017, 27, 3782-3786.

(6) Dingding Gao, Qiang Xiao, Mingming Zhang^*, Yingxia Li^*. Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors. Bioorg. Med. Chem., 2016, 24, 2549-2558.

(7) 高顶顶，包可婷, 张鸣鸣, 李英霞^*。信号转导及转录激活因子3 (STAT3)信号通路小分子抑制剂的设计、合成及其生物活性研究,有机化学, 2016, 36, 1854-1862.

(8) Haiyan Cai^#, Qiufeng Liu^#, Dingding Gao^#, Ting Wang, Tiantian Chen,Guirui Yan, Kaixian Chen, Yechun Xu*, Heyao Wang*, Yingxia Li*, Weiliang Zhu*. Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination. Eur. J. Med. Chem.2015, 90, 241-250.