高顶顶

发布者:创新中药1发布时间:2021-04-25浏览次数:1070

姓名:高顶顶性别:
职称:副研究员学历:博士研究生
专家类别:硕士生导师职务:
电话:
传真:
电子邮箱:gaodingding@shutcm.edu.cn
通讯地址:上海中医药大学2号楼5楼2520室
个人主页:

招生专业:

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
创新中药研究院理学中药学100800/中药学学术型硕士

个人简历:

2021.01-目前
副研究员,上海市中医药大学创新中药研究院手性药物研究中心
2020.07-2020.12助理研究员,上海市中医药大学创新中药研究院手性药物研究中心
2018.06-2020.06师资博后,上海中医药大学,中药学专业,合作导师:林国强院士
2012.09-2018.06博士,复旦大学,药物化学专业(导师:李英霞教授)
2008.09-2012.06本科,郑州大学,药物制剂专业

研究内容:

基于靶标的创新药物研发
源于中药的创新药物研发

学术荣誉:

上海中医药大学“杏林青年学者” 2020
上海市青年科技英才“扬帆计划” 2020
上海中医药大学“十大杏林菁英” 2020

主持科研项目:

课题名称项目名称起止时间金额
靶向肿瘤代谢新型PHGDH抑制剂的设计合成及生物活性评价国家自然科学基金青年基金 2020.01-2022.1220万
靶向肿瘤代谢新型PHGDH抑制剂的设计合成及作用机制研究上海市青年科技英才“扬帆计划”2019.05-2022.0420万
FABP4FABP5双靶点抑制剂的设计合成及生物活性评价中国博士后科学基金2018.11-2020.075万
中药活性成分牛蒡子苷元及其衍生物对STAT3信号通路的活性研究

上海中医药大学预算内科研项目2019.01-2020.125万

发表文章:

1. Cheng-Yu He#, Yun-Xuan Tan#, Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao*, Ping Tian *, Guo-Qiang Lin*. Copper(I)-Catalyzed Diastereo- and Enantioselective Construction of Optically Pure Exocyclic Allenes. Nat. Commun.2020,11, 4293. (IF=12.121)
2. Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng*, Guo-Qiang Lin, Dingding Gao*, Ping Tian*. A Retrospective Overview of PHGDH and Its Inhibitors for Regulating Cancer Metabolism. Eur. J. Med. Chem.,2021, 217, 113379. (IF=5.572)
3. Dingding Gao#, NanJin#, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, QiangXiao, Min Huang, Yingxia Li. Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. Eur. J. Med. Chem.,2021, 216, 113333. (IF=5.572)
4. Kai-Rui Feng#, Feng Wang#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li*, Guo-Qiang Lin, Dingding Gao*, and Ping Tian*. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem.,2020, 201, 112428. (IF=5.572)
5. Dingding Gao#, Xing-Yu Liu#, Hao Xu#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li*, Xiaodi Yang, Guo-Qiang Lin*, and Ping Tian*. One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 2020, 22, 4300−4305. (IF=6.091)
6. Dingding Gao+, Feng Wang+, Xing-Yu Liu, Kai-Rui Feng, Jia-Ying Zhao, Yu-Hui Wang*, Xiao-Di Yang*, Ping Tian*, and Guo-Qiang Lin. Synthesis of Decahydrocyclobuta[cd]indene Skeleton: Rhodium(III)-Catalyzed Hydroarylaton and Relay Thiophene-Promoted Intramolecular [2 + 2] Cycloaddition. Adv. Synth. Catal.2020, 362, 4384–4390 (IF=5.851)
7. Jun-Li Zhang#, Dingding Gao#, Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li*, Ping Tian*. Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 2020, 22, 3661-3666. (IF=6.091)
8. Ming-Shun Mei#, Yu-Hui Wang#, Qing Hu, Qing-Hua Li,Da-Yu Shi, Dingding Gao,* Guangbo Ge,* Guo-Qiang Lin, and Ping Tian*.Enantioselective [3 + 2] Annulation of Isatin-Derived MBH-Carbonates and 3-Nitroindoles Enabled by a Bifunctional DMAP-Thiourea. Chem. Commun.2020, 56, 10718-10721 (IF=5.996)
9. Dingding Gao#, Huixia Dou#, Haixia Su#, Mingming Zhang#, Ting Wang, Qiufeng Liu, Haiyan Cai, Zhuo Yang, Weiliang Zhu*, Yechun Xu*, Heyao Wang*, Yingxia Li*. From Hit to Lead: Structure-based Discovery of Naphthalene-1-Sulfonamide Derivatives as Potent and Selective Inhibitors of Fatty Acid Binding Protein 4. Eur. J. Med. Chem., 2018, 154, 44-59. (IF=5.572)
10. Bingbing Zhang#, Jiami Liu#, Dingding Gao#, Xiaolin Yu, Jinlei Wang, Xinsheng, Lei*. A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling. Eur. J. Med. Chem., 2019, 182, 111672. (IF=5.572)
11. Haiyan Cai#, Qiufeng Liu#, Dingding Gao#, Ting Wang, Tiantian Chen,Guirui Yan, Kaixian Chen, Yechun Xu*, Heyao Wang*, Yingxia Li*, Weiliang Zhu*. Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination. Eur. J. Med. Chem.2015, 90, 241 -250. (IF=5.572)