陶厚朝

发布者:创新中药1发布时间:2022-10-21浏览次数:72

姓名:陶厚朝性别:
职称:研究员学历:博士研究生
专家类别:博士生导师职务:
电话:
传真:
电子邮箱:houchao@shutcm.edu.cn
通讯地址:
个人主页:

招生专业:

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
创新中药研究院医学中药学100800/中药学学术型硕士

个人简历:

2021.10-目前
研究员,上海市中医药大学创新中药研究院手性药物研究中心
2014.07-2021.09副研究员,上海科技大学iHuman研究所
2008.10-2014.06研究助理,Scripps研究所,合作导师:Qinghai Zhang教授
2002.09-2008.06博士,Scripps研究所,有机化学专业(导师:Dale L. Boger教授)
1999.09-2002.06硕士,中科院上海有机化学研究所,有机化学专业(导师:俞飚教授)
1995.09-1999.07学士,南开大学,化学专业

研究内容:

中药活性分子的发现与结构优化
糖及缀合物的化学合成

主持科研项目:

课题名称项目名称起止时间金额
用于膜蛋白研究的去垢剂的合成与应用国家自然科学基金 2016.1-2020.1265万

发表文章:

  

Luo, W., Yang, M., Zhao, Y., Wang, H., Yang, X., Zhang, W., Zhao, F., Zhao, S.*, Tao, H.* Transition-Linker Containing Detergents for Membrane Protein Studies. Chem. Eur. J. 2022, 28, e202202242

Zhao, F., Zhu, Z., Xie, L., Luo, F., Wang, H., Qiu, Y., Luo, W., Zhou, F., Xue, D., Zhang, Z., Hua, T., Wu, D., Liu, Z., Le, Z.*, Tao, H.* Two-Dimensional Detergent Expansion Strategy for Membrane Protein Studies. Chem. Eur. J. 2022, 28, e202201388.

 Zhao, F., Wu, Y., Zhou, F., Xue, D., Zhao, S., Lu, W., Liu, X., Hu, T., Qiu, Y., Li, R., Gu, T., Xu, Y., Xu, F., Zhong, G., Jiang, Z., Zhao, S.*, Tao, H.* Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. J Med Chem. 2021, 64, 13830-13840.

 Hu, T., Zheng, G., Xue, D., Zhao, S., Li, F., Zhou, F., Zhao, F., Xie, L., Tian, C., Hua, T., Zhao, S., Xu, Y., Zhong, G., Liu, Z., Makriyannis, A., Stevens, R.C., Tao, H.* Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. J Med Chem. 2021, 64, 13752-13765.

 Zhou, F., Ding, K., Zhou, Y., Liu, Y., Liu, X., Zhao, F., Wu, Y., Zhang, X., Tan, Q., Xu, F., Tan, W., Xiao, Y.*, Zhao, S.* and Tao, H.*, Colocalization strategy unveils an underside binding site in the transmembrane domain of smoothened receptor. J. Med. Chem. 2019, 62, 9983-9989.

 Xue, D., Xu, T., Wang, H., Wu, M., Yuan, Y., Wang, W., Tan, Q., Zhao, F., Zhou, F., Hu, T., Jiang, Z., Liu, Z.-J., Zhao, S., Liu, D., Wüthrich, K.* and Tao, H.*, Disulfide-containing detergents (DCDs) for the structural biology of membrane proteins. Chem. Eur. J. 2019, 25, 11635-11640.

 Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P. R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.S., Cherezov, V., Stevens, R.C., Tan, W.*, Tao, H.*, and Xu, F.*, Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat. Commun. 2017, 8, 15383.

 Tao, H., Lee, S.C., Moeller, A., Roy, R.S., Siu, F.Y., Zimmermann, J., Stevens, R.C., Potter, C.S., Carragher, B., Zhang, Q.*, Engineered nanostructured β-sheet peptides protect integral membrane proteins as stable and functional single particles. Nature Methods, 2013, 10, 759-761.